The effect of T-2 toxin on the delayed potassium ion current of nerve cell membranes of the mollusk Lymnaea Stagnalis

The effect of T-2 toxin on the nerve cell membrane was investigated using 25 unidentified neurons of the visceral ganglion of the mollusc Lymnaea stagnalis .The method was performed by intracellular dialysis and perfusion of neurons under fixation of tension on these membranes.T-2 toxin within concentrations occurred between 10 -6 to 10 -3 mol / L blocked delayed potassium ion current I s k amplitude in 15( 66% )neurons out of 25 neurons investigated.The greatest decrease of the amplitude was shown under T-2 concentration of 10 3 mol /l , in which the current was 35.1 + 18.9% against the control amplitude ( 100% )the results showed that T-2 toxin revealed a cumulative action directly on the membranes of nerve cells , and confirms its high toxicity , since 10 minutes perfusion of the neuron membranes with the extracellular T-2 toxin – free solution did not fully restore I s k amplitude .